Journals on Antibiotic Resistance
Citation Listings:
Huhulescu, S. Simon, M., Lubnow, M., Kaase, M., Wewalka, G., Pietzka, A.T., et al. "Fatal Pseudomonas aeruginosa pneumonia in a previously healthy woman was most likely associated with a contaminated hot tub." Infection (2011) 39: 265-269.
This journal thesis is in the title of the article. It described the unfortunate event in a German hospital of a 49 year old woman who died due to infection from Pseudomonas aeruginosa. It depicted a cataloged list of samples taken at autopsy of the victim, and the molecular diagnostic testing done on them to prove the identification of the organism. Also samples from the hotel hot tub, showers, and sink were taken to find further evidence of the causative agent. Her pneumonia developed suddenly after ending a visit to a wellness hotel and spa while on vacation. Pseudomonas aeruginosa has exclusively been shown to inhabit soil, water, and temperature conditions above 42 degrees C. It's also known to be capable of mutating while in its host after invading its victim. The major focus of the supportive details of the journal was to inform both professionals and public health officials of the deathly nature of this organism. The article ended mentioning Austrian laws governing the use, cleaning, and maintenance of hotel spas(hot tubs), to prevent this occurrence in the future.
Kusradze, Ia, Seydina M. Diene, Goderdzishvili, Marina, Rolain, Jean-Marc. "Molecular detection of OXA carbapenemase genes in multidrug-resistant Acinetobacter baumannii isolates from Iraq and Georgia." International Journal of Antimicrobial Agents 38 (2011) 164-168.
This study involved molecular detection at the gene level for drug resistance to imipenem (IPM) of 12 Acinetobacter baumannii strains taken from various regions of the world. Two are from Belgium, eight (8) from Iraq, and two from Georgia(former Russian state). These isolates that were resistant came from war-inflicted injuries of soldiers of Iraq,(2007) and the Georgian-Russian war in 2008. The article showed the highly complex use of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry or (MALDI-TOF-MS) to identify the organisms. PCR(polymerase chain reaction) technique was used to test for the particular gene that imparts the organisms' resistance to the drugs' active site enzyme(carbapenemase). Further testing showed different strains were resistant to a host of other antibiotics as well except colistin, which is a current treatment for Acinetobacter. The read on this journal again shows the future use possibly on a consistent level of the molecular diagnostic techniques which can give doctors a faster result identification for an organism which may be resistant.
Ormerod, L.P."Multidrug-resistant tuberculosis (MDR-TB): epidemiology, prevention and treatment." June 14, 2005. British Medical Bulletin 2005; 73 and 74: 17-24.
On this workup in the bulletin a thorough delineation on how drug treatable TB became MDR-TB. It explains the two separate mutations that must occur if the transformation to resistance mode is present. The resistance is to two of the triad of standard protocol drugs for TB- isoniazid and rifampicin. The mutations as is usual operates in the organisms' gene codon sites. Due to this dual mutation MDR-TB is now classified as "basic" (just resistant to the 2 mentioned above); or "MDR-TB-plus", meaning 2 plus more antibiotics that it is shown to be resistant upon testing. The rest of the journal details the worldwide spread of the MDR-TB problem, with treatment difficulties whereby patients do not correctly stick to the regiment program prescribed by their doctor. This further enables the organism to mutate again, and to be spread by the host victim to others. The author noted that along with HIV and malaria, MDR-TB is the WHO's(World Health Organization) top 3 priorities that extended from the late 1990's on into this decade.
Patti, Gary J., Kim, Sung Joon, Yu, Tsyr-Yan, Dietrich, Evelyne, Tanaka, Kelly S.E., Parr, Thomas R., et al. "Vancomycin and Oritavancin have Different Modes of Action in Enterococcus faecium." Journal of Molecular Biology . October 9th, 2009, Volume 392,issue 5:1178-1191.
Due to increased incidence of vancomycin resistant organisms since 1986, particularly VRE(resistant entercoccus), new drugs are being developed like Oritavancin. The new antibiotic still acts upon blocking cell wall construction in the organism, but the dosage needed is less toxic (500 times less) than vancomycin. This report investigated at the chemical molecular level how the two drugs alter the cell wall synthesis of Enterococcus faecium, a clinically important pathogen seen in hospitalized patients. Oritavancin is a semi-synthetic derivative of a vancomycin analog(page 1179).
Sources in Citation List were downloaded from the Electronic Journal Center: http://blackboard.uc.edu
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